Piezoelectric sensors have many applications in geotechnical engineering, especially in characterizing soils through measurement of wave velocities. Since mechanical properties of a material are closely associated with wave velocities, piezoelectric sensors provide a reliable and non-destructive method for the determination of soil properties. This paper presents results of recent research on measuring stiffness of a wide range of soils such as clay, sand, and gravel, characterizing anisotropic properties of soil induced by external loading, measuring stiffness of base and subgrade materials in the pavement, determining soil properties in a centrifuge model during the flight of a centrifuge, and understanding wave propagation in granular materials under micro-gravity environment using this technique.