The old technique of sandblasting which has been used for paint or scale removing, deburring and glass decorating has recently been developed into a powder blasting technique for brittle materials, capable of producing micro structures larger than $100{mu}m$. In this paper, we studied on the predictive modeling of material removal and surface roughness in powder blasting of glass by design of experiments. The surface characteristics and surface shape of powder blasted glass surface were tested under different blasting parameter. Finally, we proposed a predictive model for powder blasting process, and compared with experimental results.