This paper addresses sliding mode control of the anti-lock braking system (ABS) with a disturbance observer for model uncertainties such as vehicle parameter variation, un-modeled dynamics, and external disturbances. By using a nominal vehicle model, a sliding mode controller is designed to achieve a desired wheel slip ratio for ABS control. To compensate the model uncertainties, a disturbance observer is introduced with the help of a transfer function of a hydraulic brake dynamics. A proposed sliding mode controller with a disturbance observer is evaluated through simulations for model uncertainties. The simulation results show that the disturbance observer can enhance performances of sliding mode control for ABS.