Roots of Scutellaria baicalensis have been used for fever remedy; diuresis, antiphlogistic. For the investigation of the active component from aerial parts of Scutellaria baicalensis, MeOH extracts from aerial parts of Scutellaria baicalensis were suspended with $H_2O$, and partitioned by $CHCl_3$. In order to investigate the efficacy of antioxidative activity the activity guided fraction and isolation of physiologically active substance were peformed. Its $H_2O,;30\%,;60\%$ MeOH and MeOH fractions were examined on antioxidative activity using DPPH method and TBARS assay; It was revealed that $30\%;and;60\%$ MeOH fractions have significant anti-oxidative activity. its fractions testing type I allergy, compound 48/80 induced systemic anaphylaxis was applied. As a result, compared with reference (cromolygate), these fraction significantly inhibited systemic anaphylaxis by $71\%;and;57\%$, respectively. From $30\%,;60\%$ MeOH fraction, five compounds were isolated and elucidated apigenin 6-C-${alpha}$-L-arabinopyranosyl-8-C-${eta}$-D-glucopyranoside (isoschaftside, I), scutellarein 7-O-${eta}$-D-glucuronopyranoside (scutellarin, II), apigenin 7-O- ${eta}$-D-glucuronopyranoside (III), isoscutellarein 8-O-${eta}$-D-glucuronopyranoside (IV), kaempferol 3-O-${eta}$-D-glucopyranoside (V) through their physicochemical data and spectroscopic methods. We measured radical scavenging activity with DPPH method and anti-lipid peroxidative efficacy on human LDL with TBARS assay. [$I