The design of major industrial facilities for the prevention of fatigue failure is customarily done by defining a set of transients and performing a calculation of cumulative usage factor. However, sometimes, the inherent conservatism or lack of details as well as unanticipated transients in old plant may cause maintenance problems. Even though several famous on-line monitoring and diagnosis systems have been developed world-widely, in this paper, a new system fur fatigue monitoring and life evaluation of crane is proposed to reduce customizing effort and purchasing cost. With regard to the system, at first, comprehensive operating transient data has been acquired at critical locations of crane. The real-time data were classified, by using adaptive resonance theory that is one of typical artificial neural network, into representative stress groups. Then the each classified stress pattern was mapped to calculated cumulative usage factor in accordance with ASME procedure. Thereby, promising results were obtained fur the crane and it is believed that the developed system can be applicable to other major facilities extensively.