This study was performed to examine whether HC is effective in controlling molecular components known to be involved in RA, FLS were used to determine possible regulatory effects of HC on levels of inflammatory cytokines. Major findings are summarized as follows. TNF-${alpha}$ mRNA expression levels in FLS cells which had been repressed by 10, 100 ${mu}g/m{ell}$ of HC treatment. IL-6 mRNA expression levels in FLS cells which had been repressed by 10, 100 ${mu}g/m{ell}$ of HC treatment. IL-1${eta}$ mRNA expression levels in FLS cells which had been repressed by 10, 100 ${mu}g/m{ell}$ of HC treatment. The present data suggest that FLS which has been activated by IL-1 and TNF-${alpha}$ co-treatment decreased production of inflammatory cytokines then, HC treatment by repressed the production of these molecules.