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Keum-Ryung-Ja-San, an Traditional Herbal Prescription, Ameliorates Depressive Behaviors in Mice
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  • Keum-Ryung-Ja-San, an Traditional Herbal Prescription, Ameliorates Depressive Behaviors in Mice
  • Keum-Ryung-Ja-San, an Traditional Herbal Prescription, Ameliorates Depressive Behaviors in Mice
저자명
Jung. Ji-Wook,Lee. Seung-Joo,Yoon. Byung-Hoon,Kim. Dong-Hyun,Ryu. Jong-Hoon
간행물명
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
권/호정보
2006년|14권 2호|pp.114-118 (5 pages)
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한국응용약물학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Depression is a very difficult disease to be cured because several nervous systems are involved. In the present study, we evaluated the effects of Keum-Ryung-Ja-San (KRJS), a traditional herbal prescription, on depressive behaviors in mice using the forced swimming test. KRJS was given 1 h prior to the forced swimming test (50, 100, 200, an400 mg/kg, p.o.). The duration of immobility time in the forced swimming test was significantly reduced by KRJS treatment (200 mg/kg, P<0.05) and similar effects were observed with a classical antidepressant, imipramine (15 mg/kg, i.p.). With subchronic administrations of KRJS and its constituents at several doses for 1 week, a decreased duration of immobility time was observed with KRJS and Corydalis ternata (200 mg/kg, p.o. P<0.05). These results suggest that KRJS may have antidedpressive activities and CT may contribute to the antidepressive activity of KRJS.