This paper is dealing with a 6 sigma application in chemical industries. The company is enterprise which produce PR that is semiconductor material. CTQ is consisted of thickness (Big Y$_1$) and EOP (Big Y$_2$). After 6 sigma improvement activity that thickness (Big Y$_1$) improved from 0.98 sigma to 2.80 sigma and EOP (Big Y$_2$, energy optimizer) improved from 1.53 sigma to 3.98 sigma. The effectiveness of financial scope reduced 58,200,000 won of COPQ. But there are some problems to enforce 6 sigma in small enterprises. First, it is a lack of complete charge manpower enforcing S sigma activity. Second, it is a lack of professional knowledge of project leaders. Third, the passion of sponsorship (champion) is a lacking. Nevertheless useful tool was certified so that 6 sigma achieves quality reform in small enterprises.