In this paper, we investigated the characteristics of fatigue fracture on TB(Tailored Blank) weldment by comparing the fatigue crack propagation characteristics of base metal with those of TB welded sheet used for vehicle body panels. We also investigated the influence of center crack on the fatigue characteristic of laser weld sheet of same thickness. We conducted an experiment on fatigue crack propagation on the base metal specimen of 1.2mm thickness of cold-rolled metal sheet(SPCSD) and 2.0mm thickness of hot-rolled metal sheet(SAPH440) and 1.2+2.0mm TB specimen. We also made an experiment on fatigue crack propagation on 2.0+2.0mm and 1.2+1.2mm thickness TB specimen which had center crack. The characteristics of fatigue crack growth on the base metal were different from those on 1.2+2.0mm thickness TB specimen. The fatigue crack growth rate of the TB welded specimens is slower in low stress intensity factor range $({Delta}K)$ region and faster in high${Delta}K$ region than that of the base metal specimens. The slant crack angle slightly influenced the crack propagation of the TB specimen of 2.0+2.0mm thinkness.