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[ $T_2$ ]-relaxation Time Measurement of ex vivo $^1H$ MR Metabolite Peaks for Evaluation of Human Stomach Cancer
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  • [ $T_2$ ]-relaxation Time Measurement of ex vivo $^1H$ MR Metabolite Peaks for Evaluation of Human Stomach Cancer
  • [ $T_2$ ]-relaxation Time Measurement of ex vivo $^1H$ MR Metabolite Peaks for Evaluation of Human Stomach Cancer
저자명
Mun. Chi-Woong,Choi. Ki-Sueng,Shin. Oon-Jae,Yang. Young-Ill,Chang. Hee-Kyung,Hu. Xiaoping,Eun. Chung-Ki
간행물명
Journal of biomedical engineering research : the official journal of the Korean Society of Medical & Biological Engineering
권/호정보
2006년|27권 2호|pp.53-58 (6 pages)
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대한의용생체공학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

In this study, transverse relaxation time (T2) measurement and the evaluation of the characteristics of the spectral peak related to stomach tissue metabolites were performed using ex vivo proton magnetic resonance spectroscopic imaging (MRSI) at 1.5-T MRI/S instruments. Thirty-two gastric tissues resected from 12 patients during gastric cancer surgery, of which 19 were normal tissue and 13 were cancerous tissue, were used to measure the $T_2$ of the magnetic resonance spectroscopy (MRS) peaks. The volume of interest data results from the MRSI measurements were extracted from the proper muscle (MUS) layer and the composite mucosamucosa (MCSMC) layer and were statistically analyzed. MR spectra were acquired using the chemical shift imaging (CSI) point resolved spectroscopy (CSI-PRESS) technique with the parameters of pulse repetition time (TR) and echo times (TE) TR/(TE1,TE2)=1500 msec/(35 msec, 144 msec), matrix $size=24{ imes}24$, NA=1, and voxel $size=2.2{ imes}2.2{ imes}4mm^3$. In conclusion, the measured $T_2$ of the metabolite peaks, such as choline (3.21ppm) and lipid (1.33ppm), were significantly decreased (p<0.01 and p<0.05, respectively) in the cancerous stomach tissue.