Recently, the reliability evaluation and analysis are applied far many industrial products which are required to guarantee in quality and efficiency. The purpose of this paper is to present some of reliability evaluation methodologies that are applicable to machine tools. Especially ATC (Automatic Tool Changer), which is a core component of line center, was chosen as the target of the reliability evaluation and analysis. The scope of research is reliability prediction, reliability test and evaluates their results. The results of reliability evaluation have shown the failure rates, MTBF (Mean Time Between Failure), reliability for those components of ATC and real tests reliability through the constructed reliability test-bed. It is expected that proposed methodologies would increase reliability for a high-speed line center.