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진간식풍탕가감방(鎭肝熄風湯加減方)이 중추신경계(中樞神經)에 미치는 효능에 관한 연구(硏究)
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  • 진간식풍탕가감방(鎭肝熄風湯加減方)이 중추신경계(中樞神經)에 미치는 효능에 관한 연구(硏究)
저자명
이상택,김경옥,이인,정윤관,김근우,구병수,Lee. Sang-Taek,Kim. Kyeong-Ok,Lee. Ihn,Jung. Yun-Gwan,Kim. Geun-Woo,Koo. Byung-Soo
간행물명
동의신경정신과학회지
권/호정보
2006년|17권 3호|pp.21-43 (23 pages)
발행정보
대한한방신경정신과학회
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

This study was designed to assess Effects of jingansikpungtanggagam-bang on Central Nerve System. Method : jingansikpungtanggagam-bang, a Korean traditional prescription, was evaluated for its anticonvulsant effect, hypnotic activity, analgesic action, anxiolytic effect, memory enhancement, and MAO inhibitory activity and detennined the content of neurotransmitter in brain by HPLC method. Result : 1. The extract increased potently anticonvulsant effect at 1g/kg by 5.6-fold extention of onset time against control group. 2. The extract increased hvrmsis at 500mg/kg by over twofold length of sleeping time compared to control. 3. The extract showed a significant analgesic effect with 86.0% inhibition on writhing frequency at 500mg/kg by phenylquinone-induced writhing test. 4. The extract inhibited dose-dependently the activity of monoamine oxidase in vitro. 5. This prescription increased the brain levels of serotonin and 5-hydroxyindoleacetic acid by 3.3% and 1.4%, respectively. 6. the extract exhibited the anxiolytic effect with 21.3% decrease of the immobility duration against control group. 7. the extract enhanced memory recovery on scopolamine-induced impairment of passive avoidance performance at 1g/kg pretreatment with 20.2% increase of latency time. Conclusion : The result sugguest that jiugansikpungtanggagam-bang can be used effectively as a sedative prescription in Korean traditional medicine.