MPCM (Microencapsulated Phase Change Material) slurries show several advantages over the sensible heat transportation system. In this study, a numerical model for a vapor compression refrigeration system using MPCM slurries as a secondary fluid through an evaporator was developed, and the system performance was compared with that using water. Generally, the MPCM system showed higher performance than the water system. The COP of the MPCM system was higher by 16.6 to 18.6% than that of the water system at all conditions. The MPCM slurry yields better performance in the aspect of heat transfer and heat transportation comparing to the sensible heat transfer medium such as water.