We investigated the relationship between the $TiO_2$ photocatalytic decomposition of bisphenol A in water and biological toxicity to zebrafish (Danio rerio) during $1sim28$ weeks post development stage. The bisphenol A in water was completely degraded by the $TiO_2$ photocatalysis in 50 hours. After the photocatalysis, no toxic effects on the morphogenesis of the zebrafish were observed during the development, growth, and maturate stages. Catalase activity of control group was not different from $1sim5$ week post fertilized group. However, toxic effect on the catalase activity of adult stage(28 weeks) decreased 50% than control group.