The purpose of this study was to examine the effects of chemical finishes on performance characteristics of microfiber blend fabrics. A 60% polyester microfiber /40% cotton blend woven fabric was finished by ten chemicals: three silicone softeners, one fluorochemical, and their mixtures. Performance characteristics examined were fabric hand attributes. Fabric hand was evaluated by instrumental measures using Kawabata KES-F system instruments. Silicone-only finishes did not change the bending properties significantly from those of the control fabric. The fluorochemical-only finish made the fabric stiffer and crisper. When the two chemicals were mixed they tended to offset this adversary effect. Most of the chemical finishes made the surface finer and smoother. Fluorochemical-only finish improved fabric strength. Likewise, dimethylpolysiloxane silicone improved fabric strength. Amino-functional hydrophilic and diamino-functional silicone softeners, on the other hand, reduced fabric strength. However, when mixed with the fluorochemical, the adversary effect was diminished.