Purpose: This study investigated the relationship between knowledge and attitude about smoking of college student smokers. Methods: The data were collected from the 6th to 27th of April 2005, from 411 college student smokers in Jeollabuk-Do area. The collected data were analysed by using the SPSS WIN 11.0. Results: 1) The focus group showed mean $17.40{pm}12.45$ in the knowledge about smoking. The knowledge about smoking was significantly different among general subject characteristics of age(F=4.84, p=.008), grade(t=2.96, p=.003), major(F=5.93, p=.001), and religion(t=2.96, p=.003). 2) The focus group showed mean $23.69{pm}16.19$ in their attitude about smoking. The attitude about smoking was significantly different among general subject characteristics of age(F=8.15, p=.000), grade(t=-2.33, p=.020), major(F=8.35, p=.000), and residence(t=3.08, p=.010). 3) The correlations between knowledge and attitude about smoking were positively correlated(p<0.01). Conclusion: The subjects knowledge about smoking was correlated with their attitude about smoking. Therefore, we need to develop various differential smoking prevention programs and extend the role of experts.