Purpose: This study was to investigate the effects of rehabilitation exercise program on the muscle strength and pain in elderly with knee osetoarthritis. The progressive rehabilitation program included flexibility, strength, endurance, and active range of motion exercise and functional activities. Methods: Nineteen subjects with osteoarthritis of the knees randomized to exercise group(n=10) or control group(n=9), but fourteen subjects completed the trial with an adherence of 70% to the intervention and 77% to the control. The knee pain with VAS and quadriceps strength were evaluated at pre- and post-intervention. Results: The data were analysed with the two-way repeated ANOVA and paired t-test. The pain and quadriceps muscle strength had no difference among the groups and times. Within experimental group, pain was significantly decrease and quadriceps muscle strength significantly increased between pre and post intervention, while the control group showed no changes. Conclusion: Rehabilitation exercise program for knee osteoarthirits appear to be effective in knee pain and quadriceps muscle strength.