The paper presents an optimization system which integrates a parametric design tool, 3D diffraction-radiation analysis and hydrodynamic performance assessment based on short and long term wave statistics. Controlled by formal optimization strategies the system is able to design offshore structure hulls with superior seakeeping qualities. The parametric modeling tool enables the designer to specify the geometric characteristics of the design from displacement over principal dimensions down to local shape properties. The computer generates the hull form and passes it on to the hydrodynamic analysis, which computes response amplitude operators (RAOs) for forces and motions. Combining the RAOs with short and long-term wave statistics provides a realistic assessment of the quality of the design. The optimization algorithm changes selected shape parameters in order to minimize forces and motions, thus increasing availability and safety of the system. Constraints ensure that only feasible designs with sufficient stability in operation and survival condition are generated. As an example the optimization study of a semisubmersible is discussed. It illustrates how offshore structures can be optimized for a specific target area of operation.