Recently, the development of new structural model in fixed partial denture system is required to be started from the conceptual design with low cost, high performance and quality. In this point, a FEM based design of partial denture is used to investigate stress distribution on the durable shape. In this paper, the structural performances of partial dentures were analyzed under three biting forces. The periodontal embedding model is introduced on behalf of the detailed supporting tissue, which is composed of dentin, cortical bone, cancellous bone and periodontal ligament. Using topology optimization, the optimal reinforcement layout of connector was obtained and the detail shape in the fixed partial denture was designed.