A lot of studies have investigated the role of psychosocial and behavioral risk factors in the etiology and pathogenesis of cardiovascular disease. On the basis of prospective population studies that found a relationship between Type A behavior and cardiac morbidity and mortality independent of traditional risk factors, Type A behavior was declared a risk factor for the development of coronary heart disease. Additionally, recently proposed, a new personality construct, Type D personality have been reported to be associated with the increased risk for cardiovascular morbidity and mortality. In Korea, however, there were few studies about these issues. This article attempts to provide an overview of accumulating evidences on the Type A behavioral pattern and Type D personality related with cardiovascular disease to offer new directions for research.