Sewage facilities are positively necessary for environment improvement such as rainwater removal, sewage disposal, preservation of the qualify of water and health of the citizens in present-day. Meanwhile, a deterioration of the concrete sewer pipe is increasing rapidly due to the chemical and physical attack and especially biochemical attack that is to say biodeterioration. In this study, researches for the development of antibiotics and antimicrobial concrete were conducted to reduce biochemical corrosion of sewage concrete. First of all, desired performance, such as watertightness, antibiosis, homogeneity, workability and harmlessness, was proposed and performance of antibiotics and antimicrobial concrete were evaluated by them. And developed antimicrobial concrete was applied to actual construction field. As results of this study, dispersibility and antibiosis of liquid antibiotics superior to powdery antibiotics. Antibiosis of antimicrobial concrete was verified, and amount of elution of harmful and effective ingredients was little. In workability, setting time of antimicrobial concrete was delayed. Compressive strength and resistance to carbonation of antimicrobial concrete were more increased than ordinary concrete. Finally, as there were no problems in quality and construction progress of antimicrobial concrete produced in plant, applicability of antimicrobial concrete to actual construction field was verified.