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Antioxidant and analgesic activity of Clerodendrum visconsum leaf
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  • Antioxidant and analgesic activity of Clerodendrum visconsum leaf
  • Antioxidant and analgesic activity of Clerodendrum visconsum leaf
저자명
Rahman. Shafiur,Sarder. Mokaddez,Shilpi. Jamil Ahmad,Hasan. Choudhury Mahmud
간행물명
Oriental pharmacy and experimental medicine : OPEM
권/호정보
2006년|6권 4호|pp.319-323 (5 pages)
발행정보
경희한의학연구센터
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The crude ethanolic extract of the leaves of Clerodendrum viscosum (Family: Verbenaceae) was evaluated for its antioxidant and analgesic activities to investigate the scientific basis of the traditional uses. The antioxidant property of the extract was assessed by 1, 1-diphenyl -2- picryl hydrazyl (DPPH) free radical scavenging assay. The extract showed prominent antioxidant activity ($IC_{50}about{sim}16{mu}g/ml$) which was comparable to standard drug ascorbic acid ($IC_{50}about{sim}15{mu}g/ml$).The extract produced significant (P<0.001) writhing inhibition in acetic acid induced writhing in mice at the dose of 125 mg, 250 mg and 500 mg/kg body weight respectively, which were comparable to the standard drug diclofenac sodium. The results tend to suggest that the crude leaves extract at the above doses have antioxidant and analgesic activities and indicate that it might possess biologically active constituents having free radical scavenging and analgesic activities respectably.