Purpose: This study was conducted to analysis relationship about quality of life and family burden of the home-based hospice patient families. Method: The subjects consisted of 94 families with home-based hospice patient. The ages of the subjects were 17-73 years with hospice patient who receivedhome visiting care and registered at 4 hospitals in Daegu and Kyung-Buk. The data was collected from March to November 2004. The instruments used for the study were Quality of Life Scale (GLS) and Family Burden Questionnaire (FBQ). The analysis was done using frequency, mean, standard deviation, correlation and stepwise multiple regression with SPSS WIN 11.0. Results: The results were as follows: 1. The mean score of family burden was 3.36 ($pm0.55$). The highest mean score of family burden 6 factors were wellness of future 3.85($pm1.10$), and the second was economic family burden 3.63($pm0.97$). 2. The mean score of quality of life was 3.09 ($pm0.48$). The lowest score of quality of life 6 factors were economic status 2.86($pm0.54$), and the second was physical state and function 3.01($pm0.62$). 3. In the home-based hospice patient families, family burden had significant negative correlation with quality of life(r=-0.25, p=0.012). 4. Emotional status accounted for 11% of family burden in the home-based hospice patient families by means of stepwise multiple regression. 5. Economical status accounted for 18 and age accounted for an additional 11% of quality of life in the home-based hospice patient families by means of stepwise multiple regression. Conclusion: The finding showed that family burden and quality of life of home-based hospice patient families were significantly negative correlation and the highest factor of family burden was wellness of future and the most important factor of quality of life was economic status.