The purpose of this research is to study if the images that make-up advertisement tries to symbolize can be altered with changes only in the colors of make-up and without any changes in other factors and if colors can be tools of communication in image. Also, we studied the interaction between the partial changes of eyes and lips. The results are as follows. First, we studied if the images that make-up advertisement tries to symbolize can be altered with changes only in the colors of make-up and without any changes in other factors. The study revealed more or less differences, however, when we applied colors of each image on photos, people had higher recognition on that image more than other images. Therefore, we can conclude that the image can be changed merely with the change from colors of make-up. Second, we changed the make-up colors of lips and eyes separately and studied the interaction of the two. When natural colors and elegant color were applied, there was no interaction of color application between eyes and lips within 0.1 significance level. In the case of romantic colors, there was interaction of applying colors between lips and eyes within 0.1 significance level. When we applied gorgeous colors and modern colors, there was interaction of applying colors between lips and eyes within 0.1 significance level. Therefore, from the interaction of the two, it was recognized to be most gorgeous or most modern when gorgeous colors or modern colors were applied in both lips and eyes.