Purpose: The purpose of this study was to investigate the effect of wrist position on grip strength. A Grip-Strength is measurement of muscle strength in hand. It is evaluated for the motor function and handicap of hand, projection of treatment plan. It is important because correct treatment. Methods: Total 80 college students were participated in this study, who consisted of 40 males and 40 females(age range: $20{sim}26$). A Grip-Strength Dynamometer was used to measure the grip strength in three wrist position(flexion, extension, neutral position) and two elbow position(supination, pronation). The ANOVA was conducted to determine any significant difference in grip strength between the wrist position and the two elbow position. Results: The results were as follows: 1. The grip strength was affected by wrist position changes. 2. The difference of grip strength according to elbow position Was not significant difference (p>0.01). 3. The grip strength i1l neutral position was strongest among 3 position of wrist (p<0.01). Conclusion: A Grip-Strength was significant difference in wrist position. Pronation position was minimum grip-strength but not significant difference between supination and pronation.