Quality assurance (QA) for nuclear R&D project is very concerned about the poor economy due to the improper selection of QA requirements. This paper proposes a new methodology for determining the relative importance weights of QA requirements considering the attributes of nuclear R&D project. QFD (Quality Function Deployment) is used as a conceptual framework and fuzzy number is introduced to capture the vagueness uncertainty existing in human judgement. Also we use a confidence attitude of decision-maker in order to improve the reliability of extracted attribute level of R&D project. Case study on a nuclear R&D project and scenario analysis are carried out to verify the usefulness and effectiveness of proposed methodology.