Purpose: This study was done to determine the effect of Tai-Chi Self-help program to progress of reduction of symptom, difficulty on activity by application Tai-Chi Self-help program for Fibromyalgia patients. Method: The study was used the method of one group pretest-posttest design. The subjects were 65 outpatients who were diagnosed as Fibromyalgia by ACR(1990) standard at K University Hospital, medical center. Tai-Chi self-help program was done for 8 weeks(three a week for 2 hours)through group meeting of 65 patients. Collected data were analyzed by SPSS for window12.0 program package. Results: The result of this study suggests that could increase in reduction of symptom and lower disturbance in ADL and life Satisfaction compared with the before Tai-Chi Self-help program education. Conclusion: Accoradingly Tai-Chi Self-help program could be used as a proper nursing strategy for Fibromyalgia patients.