Purpose: The purpose of this paper is to report the effect of oriental medicine to unexplained secondary infertility. Methods: The patient was 40 years-old female whose case was diagnosed as unexplained secondary infertility. On purpose to pregnant, she had being treated with IVF(in vitro fertilization) and oriental medicine at once. But she had failed IVF in twice, who was treated with oriental medicine only constantly. Results: On course of failing IVF again, the patient was treated with Oriental medicine constantly. After she had stopped IVF who was treated only oriental medicine. And she became pregnant. Conclusion: According to this result, we concluded that oriental medicine could improve fertility rate. After this paper, futher study and clinical approach based on oriental medicine will be needed about unexplained infertility.