Since the concept of "innovation resistance" was introduced as a summary construct for customers not adopting a superior innovation, a lot of researchers have examined to identify the relationship between the innovation resistance and the various innovation and situation variables. This paper addresses the innovation resistance coming from the introduction of a new R&D grant management system(RGMS) in a university. The new RGMS is based on research grant management policies newly accredited by the government, where the central management of the research grants is indispensable. We have surveyed professors and researchers about the introduction of a new RGMS, and empirically analyzed the perceived innovation characteristics and the user characteristics affecting the innovation resistance. The result shows that perceived risk is the most important factor influencing on the innovation resistance.