There are very necessary for three factors, that is sun(oxygen), temperature, nutritions to maintain life. when sun shines, skin temperature get up. after man eat food, core body temperature get higher. temperature is temperature. therefore, common characteristic of three factors is temperature. temperature is energy and qi(氣) in korean medicine. in addition to this one, pyretomedicine also insists that the key point of all disease development mechanism is also the overenough and poor of energy. In this aspects, writer submit this thesis about all disease development, neoplasia devolpment and metastasis as hypothesis.