The purpose of this study is to examine and compare the concentrations of blood retinol and $alpha$-tocopherol in normal and diarrhea calves. The subjects of the experiments are from three groups. Each group consists of 5 calves(diarrhea, treatment and control group). The CBC, serum chemistry, serum retinol and a-tocopherol concentrations were estimated in each group. Blood retinol concentration was $13.3{pm}7.0{mu}g/100ml$ in diarrhea group, $31.5{pm}6.9{mu}g/100ml$ in treatment group and $28.1{pm}11.8{mu}g/100ml$ in the control group. The blood concentration in diarrhea group was significantly lower than that of the control group in the case of retinol(p<0.05). However, there were no significance between the treatment poop and the control group. The $alpha$-tocopherol concentration in blood was $266.0{pm}127.6{mu}g/100ml$ in diarrhea group, $432.2{pm}172.7{mu}g/100ml$ in the treated group and $579.3{pm}145.8{mu}g/100ml$ in the control group. In the case of $alpha$-tocopherol, the laboratory group were significantly lower than the control group(p<0.05), except for the treatment group. As in retinol concentration there were no significance between treatment group and the control group. In the test of CBC, PCV was significantly lower in the group with diarrhea than the control group(p<0.05). Fibrinogen concentrations in diarrhea calves were significantly higher than the treatment and control group. In conclusion, the blood retinol and $alpha$-tocopherol concentration in diarrhea calves are lower than normal calves. Medication of retinol and $alpha$-tocopherol on calves with diarrhea is recommended.