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건강한 미니돼지에서 간담도 기능의 핵의학적 평가
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  • 건강한 미니돼지에서 간담도 기능의 핵의학적 평가
  • Scintigraphic Assessment of Hepatobiliary Functions in Healthy Miniature Pigs
저자명
김세은,심경미,유경훈,이원국,최석화,박수현,한호재,강성수,Kim. Se-Eun,Shim. Kyung-Mi,Yoo. Kyeong-Hoon,Lee. Won-Guk,Choi. Seok-Hwa,Park. Soo-Hyun,Han. Ho-J
간행물명
Journal of veterinary clinics
권/호정보
2007년|24권 4호|pp.593-596 (4 pages)
발행정보
한국임상수의학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The purpose of this study is to investigate normal hepatobiliary functions in healthy miniature pigs. $^{99m}Tc-DISIDA$ hepatobiliary scintigraphy(HBS) was used for it. Five mCi dose of $^{99m}Tc-DISIDA$ was injected intravenously into 3 healthy adult miniature pigs, and dynamic images were obtained during 1 hour. $^{99m}Tc-DISIDA$ HBS in a miniature pig was evaluated for 6 variables. A cardiac washout occurred within 1 min in all miniature pigs and radioactivities in the gallbladder were not detected in two miniature pigs. Thus, the initial radioactivity and Tmax of the gallbladder were non-available to identify. Mean Tmax of liver was $8.67{pm}2.08$ min and initial small intestinal radioactivity was seen at $9.67{pm}2.52$ min after $^{99m}Tc-DISIDA$ injection. Mean hepatic washout time was not detected in 60 min dynamic images. Therefore, $^{99m}Tc-DISIDA$ HBS is the effective diagnostic method to evaluate the function of hepatocyte and bile flow rate. However, it was not a proper method to evaluate the function of gallbladder, which indicates that an additional study is needed to further specify the reasons for the absence of radioactivities in gallbladder of two miniature pigs.