Medial axis transform (MAT) is very sensitive to noise, in the sense that, even if a shape is perturbed only slightly, the Hausdorff distance between the MATs of the original shape and the perturbed one may be large. Recently, Choi et al.(2002) showed that MAT is stable for a class of 2D domains called weakly injective, if we view this phenomenon with the one-sided Hausdorff distance, rather than with the two-sided Hausdorff distance. In this paper, we extend this result to general 2D domains with natural boundary regularity. We also present explicit bounds for this general one-sided stability of the 2D MAT.