Optimum injection molding condition for a box mold was searched by the Response Surface Analysis(RSA) with the aid of process monitoring system(PMS). Process variables on the control panel of the injection molding machine such as barrel temperatures, screw speed profile, holding pressures, etc. cannot guarantee the uniformity of the material variables directly related with the state of the product in the mold cavity. In order to make sure the state of the resin in the cavity, pressures and temperatures in the cavity, runner and nozzle were monitored in the experiment with the PMS. To accomplish the consistency of the molding process, dependent variables such as the switchover point and holding time were searched with the PMS. With a proper objective function about deflection of the box-type product, the optimum injection molding condition was obtained.