A series of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-substitutedphenylamides (2a-n) were synthesized and their ability to inhibit nuclear factor-${kappa}B$ activity was evaluated in lipopolysaccharide (LPS)-stimulated macrophage RAW 264.7 cells. While compounds bearing -OH, or $-OCH_3$ substituents were inactive, compounds with $-CH_3,;-CF_3$, or -CI substituents were potent inhibitors ($IC_{50}:;6.0-60.2{mu}M$). The most active compound, 2n, contained a 4-CI substituent on the phenyl ring and was four times more potent than the compound KL-1156.