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Interaction of ${varepsilon}-L-{eta}-lysine$ as a Tail Analogy of Tallysomycin-A to a Double Helical DNA Oligonucletide $d(CGCTTCGAAGCG)_{2}$, was investigated by NMR
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  • Interaction of ${varepsilon}-L-{eta}-lysine$ as a Tail Analogy of Tallysomycin-A to a Double Helical DNA Oligonucletide $d(CGCTTCGAAGCG)_{2}$, was investigated by NMR
  • Interaction of ${varepsilon}-L-{eta}-lysine$ as a Tail Analogy of Tallysomycin-A to a Double Helical DNA Oligonucletide $d(CGCTTCGAAGCG)_{2}$, was investigated by NMR
저자명
Lee. Chang-Jun,Won. Ho-Shik
간행물명
Journal of the Korean magnetic resonance society
권/호정보
2007년|11권 2호|pp.129-137 (9 pages)
발행정보
한국자기공명학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

During the screening of material which has the antimicrobial activity against aminoglycoside-resistant bacteria, A new material ${varepsilon}-(L-{eta}-lysine)$ polypeptide from a culture medium of Streptomyces sp.(DWGS2) was isolated, and the structure and the physicochemical properties of the new material were elucidated. The new material was separated by column chromatography of the culture medium using Dowex $1{ imes}2$, Silica gel, and Sephadex LH20 etc. The structure and molecular weight were determined with the data of NMR, MALDI mass, and ESI mass experiments. And the monomer obtained by hydrolysis of the new material with 6N-HCI was identified as a $L-{eta}-lysine(T_2)$, which is a tail of bleomycin. As tail-region analogy, $T_2({eta}-lysine$ derivatives from streptomyces) interactions with a self-complementary oligonucleotides, $d(CGCTTCGAAGCG)_2$, was investigated by NMR.