Purpose: This study has been attempted in order to confirm the factors that affect the healthpromotion lifestyle of nurses. Method: Data was collected by questionnaires from 324 nurses at 5 university hospitals located in Seoul. The instrument tools utilized in this study was health-promotion lifestyle, perceived health status, perceived benefits, perceived barriers, self-efficacy, and social support, and validity and reliability of the tool have been verified with literature studies and pre-study examinations. The collected data have been analyzed using SPSS PC 12 program. Result: The factors that affect health-promotion lifestyle of nurses were perceived health status ($eta$= .320), self-efficacy ($eta$= .248), social support ($eta$= .139), perceived benefits ($eta$= .207), and age ($eta$= .089), that altogether explained 41.1%. Conclusion: It has been confirmed that th regression equation model of this research may serve as a health- promotion lifestyle prediction factors in nurses.