The studies with respect to micro-channels and micro-mixers are expanding in many dimensions. Most significant area of micro-mixer study is the flow analysis in various micro-channel configurations. The flow phenomena in micro-channel devices are quite different from that of the macro-scale devices. An attempt is made here to review the important recent literature available in the area of micro-channel flow analysis and mixing. The topics covered include the physics of flow in micro-channels and integrated simulation of the micro-channel flow. Also, the flow control models and electro-kinetically driven micro-channel flows are dealt in detail. A survey of important numerical methods, which are currently popular for micro-channel flow analysis, is carried out. Different options for mixing in micro-channels are provided, in sufficient detail.