Purpose: The purpose of this study was to investigate the relationship between critical thinking disposition and self-efficacy of college nursing student. Method: Data was collected from 186 nursing students in D and M cities. Result: The average scores were; critical thinking disposition 62.59 and self efficacy 88.91. The critical thinking disposition level was significantly different according to the general characteristics of the high school system. The self-efficacy level was significantly different according to the general characteristics of gender. The critical thinking disposition level and self-efficacy level showed a positive correlation(r=.335, p<.000). Conclusion: A strategy for development of the critical thinking disposition and self-efficacy is needed for nursing students.