In order to evaluate the integrity of Zr-2.5Nb pressure tubes, probabilistic fracture mechanics(PFM) approach was employed. Failure assessment diagram(FAD), plastic collapses, and critical crack lengths(CCL) were used for evaluating the failure probability as failure criteria. The Kr-FAD as failure assessment diagram was used because fracture of pressure tubes occurred in brittle manner due to hydrogen embrittlement of material by deuterium fluence. The probabilistic integrity evaluation observed AECL procedures and used fracture toughness parameters of EPRI and recently announced theory. In conclusion, the probabilistic approach using the Kr-FAD made it possible to determine major failure criterion in the pressure tube integrity evaluation.