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환경성 PAHs 노출과 생체지표 연구
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저자명
이경호,이충민,조수헌,권호장,강대희,Lee. Kyoung-Ho,Li. Zhung-Min,Cho. Soo-Hun,Kwon. Ho-Jang,Kang. Dae-Hee
간행물명
Journal of toxicology and public health : an official journal of the Korean Society of Toxicology
권/호정보
2007년|23권 1호|pp.39-46 (8 pages)
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한국독성학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

The aim of the study was to see if there is any differences in urinary 1-hydroxypyrene glucuronide (1-OHPG) and 2-naphthol levels in children ($8{sim}14$ years old) and their mothers ($30{sim}46$ years old) living three cities in South Korea (Seoul, Incheon and Pohang) and three in China (Changchun, Datong and Kunming), where the levels of air pollution varies. The factors related with urinary biomarkers levels were also evaluated. The study subjects consisted of 118 Korean (60 children and 58 their mothers) and 120 Chinese (60 children and 60 their mothers). Urinary 1-OHPG was measured by synchronous fluorescence spectroscopy after immuno-affinity purification using monoclonal antibody 8E11 and urinary 2-naphthol concentrations were determined by HPLC with fluorescence detector. Information on recent consumption of diet containing high PAHs, environmental tobacco smoke (ETS), type of cooking and heating fuels, and other life-style characteristics were collected by self-administered questionnaire. The arithmetic mean of urinary 1-OHPG levels (n = 120, $mean{pm}SD$, $6.77{pm}7.96{mu}mol/mol$ creatinine) in Chinese were 10 fold higher than those in Korean (n = 118, $0.62{pm}0.61{mu}mol/mol$ creatinine) (P < 0.01). Urinary 2-naphthol levels in Chinese (n = 119, $59.50{pm}82.29{mu}g/g$ creatinine) were significantly higher than those in Korean (n = 117, $25.09{pm}46.56{mu}g/g$ creatinine) (P < 0.01). Urinary 1-OHPG and 2-naphthol levels were significantly higher in children living the polluted cities in China (Datong and Chanchun, respectively). Multiple linear regression analysis indicated that living in factory area (vs. residential area) and use of coal stove as heating fuel were significant predictors for urinary 1-OHPG (overall model $R^2$= 0.46, n = 204). And ETS was predictor for urinary 2-naphthol levels in Korean ($R^2$ = 0.36, n = 46). These results indicated that urinary 1-OHPG and 2-naphthol levels were related with different ambient particulate air pollution, type of heating fuels and ETS.