Steam generator tubes are degraded from wear, stress corrosion cracking, rupture and fatigue and so on. Therefore, the failure assessment of steam generator tube is very important for the integrity of energy plants. In the steam generator tubes, sometimes, the local wall thinning may result from severe degradations such as erosion-corrosion damage and wear due to vibration. In this paper, the elasto-plastic analysis was performed by FE code ANSYS on steam generator tubes with wall thinning. Also, the four-point bending tests were performed on the wall thinned specimens, and then it was compared with the analysis results. We evaluated the failure mode, fracture strength and fracture behavior from the experiment and FE analysis. Also, it was possible to predict the crack initiation point by estimating true fracture ductility under multi-axial stress conditions at the center of the thinned area from FE analysis.