Purpose: This study investigated the factors affecting the attitudes of health care professional students toward physically disabled students. Method: The data was collected from 415 health care professional students in one university using a structured questionnaire. The data was analyzed using descriptive analysis, t-test, one-way ANOVA, and stepwise multiple regression by SPSS 12.0. Results: The mean score for attitude was 3.49(SD=.27). There were significant differences in the mean score for attitude according to gender, major, family with disability, having social interactions and meeting as a clinical case. The attitudes of health care professional students correlated to the gender and having social interactions $(R^2=38%)$. Conclusion: This study revealed that intimate contact is the most effective factor for health care professional students to have a positive attitude toward students with physical disabilities.