Purpose: This study examined the effects of Interpersonal Relationship Improvement Program Applied MMTIC on self-esteem and interpersonal relationships. Method: The survey was carried out from September to November, 2005. The subjects were 32 middle school students in G City. To test the effects of the Interpersonal Relationship Improvement Program Applied MMTIC, the subjects were divided into two groups, 16 in the experimental group and 16 in the control group. The research design used in this study was a nonequivalent control group pre-test and post-test design in quasi-experimental research. The research tools included MMTIC(Murphy-Meisgeier Type Indicator for Children), self-esteem scale, and interpersonal relationship scale. The collected data was analyzed using Chi-square test, paired t-test, and t-test on the SPSS/WIN 10.0 program. Result: Significant differences were found in the self-esteem scores and interpersonal relationship between the middle school students who had participated in the Interpersonal Relationship Improvement Program Applied MMTIC and those who did not. Conclusion: Therefore, it appears that the Interpersonal Relationship Improvement Program Applied MMTIC is a useful nursing intervention for improving the self-esteem and interpersonal relationships of middle school students.