Stereoselective Synthesis of L-threo-Sphingosine, L-threo-Sphinganine, D-threo-Sphingosine, and D-threo-Sphinganine via Oxazoline Formation and Olefin Cross-Metathesis; Potent Protein Kinase C Inhibitor Analogues

Stereoselective Synthesis of L-threo-Sphingosine, L-threo-Sphinganine, D-threo-Sphingosine, and D-threo-Sphinganine via Oxazoline Formation and Olefin Cross-Metathesis; Potent Protein Kinase C Inhibitor Analogues
Stereoselective Synthesis of L-threo-Sphingosine, L-threo-Sphinganine, D-threo-Sphingosine, and D-threo-Sphinganine via Oxazoline Formation and Olefin Cross-Metathesis; Potent Protein Kinase C Inhibitor Analogues

ㆍ 저자명: Tian. Yong-Shou,Joo. Jae-Eun,Pham. Van-Thoai,Lee. Kee-Young,Ham. Won-Hun
ㆍ 간행물명: Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
ㆍ 권/호정보: 2007년|30권 2호|pp.167-171 (5 pages)
ㆍ 발행정보: 대한약학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

서지반출

기타언어초록

In this study, we explored a convenient and concise route for synthesis of L-threo-sphingosine, D-threo-sphingosino, L-threo-sphinganine and D-threo-sphinganine from commercially available L- or D-serine. The key steps are the simple preparation of trans-oxazoline and intermolecular olefin cross metathesis.

키워드

Sphingolipid Sphingosine Sphinganine Safingol Ceramide Amino alcohol

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