Purpose : Postnatal depression is a major public health problem. The aim of this study is to investigate the relation between Edinburgh postnatal depression scale and Heart rate variability in the Early Postpartum. Methods : The subjects were 33 women who admitted for postpartum treatment in Hospital of Woosuk University from 13th October to 8th December 2006. 33 women filled out an EPDS, general questionnaire and then they took the test of Heart rate variability at 3th day after normal spontaneous vaginal delivery. We studied the results to investigate the relation between EPDS and HRV. Results: 1. Mean age of risk group of depression is larger than non-risk group. 2. SDNN, RMSSD and SDSS of non-risk group of depression significantly increased compared with that of risk group. 3. Ln(TP), Ln(HF) of non-risk group of depression significantly increased compared with that of risk group. Conclusion : The results suggest that there were significant differences on HRV between risk group and non-risk group of early postpartum depression examined by EPDS.