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The Anti-hyperlipidemic Effect and Constituents of the 19${alpha}$-Hydroxyursane-type Triterpenoid fraction Obtained from the Leaves of Rusus crataegifolius
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  • The Anti-hyperlipidemic Effect and Constituents of the 19${alpha}$-Hydroxyursane-type Triterpenoid fraction Obtained from the Leaves of Rusus crataegifolius
  • The Anti-hyperlipidemic Effect and Constituents of the 19${alpha}$-Hydroxyursane-type Triterpenoid fraction Obtained from the Leaves of Rusus crataegifolius
저자명
Nam. Jung-Hwan,Jung. Hyun-Ju,Tapondjou. Leon Azefack,Lee. Kyung-Tae,Choi. Jong-Won,Kim. Won-Bae,Park. Hee-Juhn
간행물명
Natural product sciences
권/호정보
2007년|13권 2호|pp.152-159 (8 pages)
발행정보
한국생약학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

To demonstrate anti-hyperlipidemic activity of the 19${alpha}$-hydroxyursane-type triterpenoid (19${alpha}$-HUT)-rich fraction, this fraction was prepared from the extract of Rubus crataegifolius leaves. This fraction was found to have anti-hyperlipidemic effect in a high fat diet-induced rat model from the observation of reduction of abdominal fat pad weights, atherogenic index and hypercholesterolemia at 30 and 60 mg/kg (p.o.) The 19${alpha}$-HUT fraction was subjected to SiO$_2$, ODS, and/or Sephadex LH-20 column chromatography to yield a new triterpenoid (1) called pomolic acid ester along with nine known triterpenoids which are all 19${alpha}$-HUTs: euscaphic acid (2), tormentic acid (3), 23-hydroxytormentic acid (4), kaji-ichigoside F$_1$ (5), rosamultin (6), niga-ichigosides F$_1$ (7) and F$_2$ (8), suavissimoside F$_1$ (9) and coreanoside F$_1$ (10). The structure of compound 1 was established as 28-O-formyl-3,19-dihydroxyurs-12-en-28-oic acid on the basis of 2D-NMR spectroscopic data and mass spectrum. Compound 1 was isolated for the first time from natural sources.