HL7 is well-Known standard protocol for text data generated in hospital information systems. In this paper, we have to design to obtain useful vital sign information, which is generated at data receiver modulor of HIS, that is offered by the central monitor. Vital sign informations of central monitor is composed of the row data of several bedsite patient monitors. We are willing to maintain vital sign information of real time and continuity that is generated from the bedsite patient monitor. It is able to apply to remote medical examination and treatment. we proposed integration method between vital sign database systems and hospital information systems. Through the proper exchange and management of patient vital sign information, real time vital sign information management will offer better workflow to all hospital employee.