This article addresses the question of how the operational architecture for a railway safety information system should be developed. A successful railway safety information system can be developed by fully reflecting the business process and needs at the enterprise level. To date, there has been minimal research effort towards the development of the operational architecture for a railway safety information system. To this end, a variety of enterprise architectures have been studied so far. In this paper, as an important guideline, DoDAF (Architecture Framework) is selected to be used in developing a railway safety information system. In particular, we propose a method to implement the operational architecture based on DoDAF.