This study deals with the improvement of production process on a flow production system with the consideration of six sigma. We analyze the production process and survey the important factors of improvement of productivity. Using a six sigma, we find strategic point and suggest a reformation of production process. We applied a simulation technique to simulate the production line proposed by the result of the Six sigma. With the result of the simulation, this study analyzes the propriety of production line and proposes the alternatives of new production process.